TMEM217

Across TCGA patient cohorts, TMEM217 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,151 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TMEM217-associated GO terms across cancer lineages are Positive regulation of non-canonical NF-kappaB signal transduction, Non-canonical NF-kappaB signal transduction, and Phosphatidylinositol phosphate biosynthetic process. Each is linked with TMEM217 in more than 22 cancer types. Because this analysis shows association rather than direction, both TMEM217-to-partner and partner-to-TMEM217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of non-canonical NF-kappaB signal transduction grouped by TMEM217-low versus TMEM217-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM217→partner) and Y-score (partner→TMEM217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of non-canonical NF-kappaB signal transduction →	+0.036	+0.225	<.001	<.001	3	23
STAD	Non-canonical NF-kappaB signal transduction →	+0.034	+0.185	<.001	<.001	3	23
LAML	Phosphatidylinositol phosphate biosynthetic process →	+0.040	+0.939	<.001	<.001	3	23
STAD	Regulation of proteasomal protein catabolic process →	+0.062	+0.237	<.001	<.001	3	23
STAD	Positive regulation of canonical NF-kappaB signal transduction →	+0.062	+0.290	<.001	<.001	3	23
PAAD	Cell-substrate junction organization →	+0.037	+0.412	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,151 associations by consensus.

Positive regulation of non-canonical NF-kappaB signal transduction by TMEM217 expression — STAD

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