TMEM217

Across TCGA pan-cancer cohorts, TMEM217 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM217 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TMEM217 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM217 expression acts as an unfavorable survival marker, although some lineages such as UVM and CESC show a favorable association.

LUSC, LGG, and UVM are the cancer types where TMEM217 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.312	0.466	<.001	100	view →
LGG	OS	Median	All	0.725	0.891	<.001	50	view →
UVM	DFS	Quartile	All	0.812	0.417	.002	47	view →
CESC	OS	Quartile	IV	1.000	0.185	.004	32	view →
LUAD	OS	Median	III,IV	0.655	0.358	.008	16	view →
CHOL	DFS	Median	II,III,IV	0.138	0.611	.013	16	view →
LIHC	OS	Median	II,III,IV	0.570	0.327	.016	14	view →
BRCA	OS	Median	III,IV	0.852	0.960	.001	13	view →
UCEC	OS	Median	II,III,IV	0.273	0.730	.008	12	view →
OV	OS	Quartile	All	0.760	0.667	.027	10	view →
THYM	OS	Median	II,III,IV	1.000	0.891	.014	9	view →
READ	OS	Quartile	III,IV	1.000	0.330	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM217–LUSC (DFS)

Open the LUSC breakdown →