TMEM217

Across TCGA patient cohorts, TMEM217 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM217-associated genes across cancer lineages are 4E-BP1, IGFBP2, and INPP4B. Each is linked with TMEM217 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM217-to-partner and partner-to-TMEM217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TMEM217-low versus TMEM217-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM217→partner) and Y-score (partner→TMEM217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.350	+2.415	.001	.003	3	2
UCEC	IGFBP2 →	-0.836	-1.906	.001	.016	3	1
UCEC	INPP4B →	-0.349	-3.584	.007	.002	3	1
UCEC	JNK2 →	+0.183	+2.834	.022	.034	3	1
UCEC	MEK1 →	+0.396	+3.000	.007	<.001	3	1
UCEC	mTOR_pS2448 →	-0.124	-2.308	.038	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1 by TMEM217 expression — UCEC

Explore this box plot interactively →