Across TCGA cell cohorts, TMEM215 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM215-associated genes across cancer lineages are DMRTC2, OR14K1, and OR10AC1. Each is linked with TMEM215 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM215-to-partner and partner-to-TMEM215 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM215→partner) and Y-score (partner→TMEM215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DMRTC2 →	+0.204	+4.523	<.001	.003	3	1
LUNG_SCLC	OR14K1 →	+0.093	+4.269	.001	.005	3	1
LUNG_SCLC	OR10AC1 →	+0.080	+4.269	<.001	.005	3	1
LUNG_SCLC	GAGE12J →	+1.793	+4.044	<.001	.009	3	1
LUNG_SCLC	OR56A1 →	+0.094	+3.987	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

TMEM215 survival (RNA) · tumor vs normal (RNA) · all TMEM215 data types