TMEM209

Across TCGA pan-cancer cohorts, TMEM209 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMEM209’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM209 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM209 is over-expressed in tumor.

COAD, LSCC, and HNSC are the cancer types where TMEM209 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM209 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.406	<.001	10	view →
LSCC	Male	All	+0.583	<.001	9	view →
HNSC	All	IV	+0.319	<.001	9	view →
LUAD	Female	All	+0.288	<.001	8	view →
PDAC	All	IV	+0.627	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMEM209–COAD

Open the COAD breakdown →