TMEM209

Across TCGA pan-cancer cohorts, TMEM209 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM209 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM209 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM209 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LUAD show a favorable association.

UVM, KICH, and LGG are the cancer types where TMEM209 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.294	0.823	<.001	97	view →
KICH	OS	Quartile	All	0.521	1.000	.002	51	view →
LGG	OS	Median	All	0.720	0.903	<.001	51	view →
CESC	DFS	Quartile	II,III,IV	0.506	0.832	.002	48	view →
LUSC	DFS	Quartile	All	0.823	0.696	.002	47	view →
LIHC	DFS	Tertile	All	0.424	0.594	.001	37	view →
HNSC	OS	Quartile	All	0.231	0.537	.001	28	view →
KIRP	OS	Median	III,IV	0.637	0.877	.012	26	view →
PAAD	OS	Tertile	II,III,IV	0.509	0.808	.006	26	view →
LUAD	DFS	Tertile	IV	0.931	0.240	.011	17	view →
SCLC	DFS	Median	All	0.579	0.928	.005	13	view →
MESO	DFS	Median	III,IV	0.245	0.596	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM209–UVM (DFS)

Open the UVM breakdown →