TMEM209

Across TCGA patient cohorts, TMEM209 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM209-associated genes across cancer lineages are EGFR_pY1068, MEK1, and MSH2. Each is linked with TMEM209 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM209-to-partner and partner-to-TMEM209 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM209-low versus TMEM209-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM209→partner) and Y-score (partner→TMEM209) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.268	-2.321	.033	.035	3	1
UCEC	MEK1 →	+0.410	+2.321	.025	.035	3	1
UCEC	MSH2 →	-0.245	-2.321	.034	.035	3	1
UCEC	mTOR_pS2448 →	-0.164	-2.321	.029	.035	3	1
UCEC	Annexin-1 →	+0.723	+3.019	.006	.019	3	1
UCEC	Shc_pY317 →	-0.197	-3.459	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by TMEM209 expression — UCEC

Explore this box plot interactively →