TMEM209

Across TCGA cell cohorts, TMEM209 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,984 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM209-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of telomeric D-loop disassembly, and Mismatch repair. Each is linked with TMEM209 in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM209-to-partner and partner-to-TMEM209 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by TMEM209-low versus TMEM209-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM209→partner) and Y-score (partner→TMEM209) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of isotype switching to IgG isotypes →	+0.125	+0.723	<.001	.002	3	16
SOFT_TISSUE	Regulation of telomeric D-loop disassembly →	+0.133	+1.145	<.001	<.001	3	13
BONE	Mismatch repair →	+0.107	+0.785	.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.099	+1.150	<.001	<.001	3	13
BLOOD_Lymphoma	Regulation of microtubule-based process →	+0.038	+0.797	<.001	<.001	3	12
CNS	DNA strand invasion →	+0.108	+0.558	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by TMEM209 expression — PANCREAS

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