TMEM208

Across TCGA patient cohorts, TMEM208 mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM208-associated genes across cancer lineages are RNA5SP422, KRTAP20-3, and LINC01078. Each is linked with TMEM208 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM208-to-partner and partner-to-TMEM208 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by TMEM208-low versus TMEM208-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM208→partner) and Y-score (partner→TMEM208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP422 →	+1.248	+2.671	<.001	.002	3	2
LUAD	KRTAP20-3 →	+0.248	+7.930	<.001	.008	3	1
LUAD	LINC01078 →	+0.084	+7.930	<.001	.008	3	1
LUAD	LINC02791 →	+0.139	+7.930	<.001	.008	3	1
LUAD	YWHAEP2 →	+0.497	+7.930	<.001	.008	3	1
UCEC	SENP3-EIF4A1 →	+0.153	+3.523	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

RNA5SP422 by TMEM208 expression — UCEC

Explore this box plot interactively →