TMEM200A

Across TCGA pan-cancer cohorts, TMEM200A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TMEM200A data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM200A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM200A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LIHC, and ACC are the cancer types where TMEM200A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.298	.001	30	view →
LIHC	DFS	Median	All	0.076	0.553	.002	24	view →
ACC	DFS	Median	All	0.066	0.667	.002	12	view →
ESCA	DFS	Median	II,III,IV	0.179	0.525	.019	12	view →
HNSC	OS	Median	IV	0.254	0.711	.014	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.006	0.611	<.001	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.785	0.674	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TMEM200A–UCEC (DFS)

Open the UCEC breakdown →