TMEM196

Across TCGA patient cohorts, TMEM196 mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM196-associated genes across cancer lineages are OR5H7P, RPL19P1, and LINC01072. Each is linked with TMEM196 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM196-to-partner and partner-to-TMEM196 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5H7P grouped by TMEM196-low versus TMEM196-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM196→partner) and Y-score (partner→TMEM196) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5H7P →	+0.041	+4.730	<.001	.005	3	2
LUAD	RPL19P1 →	+0.109	+4.995	<.001	<.001	3	2
UCEC	LINC01072 →	+0.191	+2.810	<.001	.002	3	2
SKCM	MIR8082 →	+0.391	+3.490	<.001	.008	3	1
SKCM	MIR6729 →	+0.284	+4.469	<.001	.006	3	1
UCEC	SREK1IP1 →	+0.473	+3.584	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

OR5H7P by TMEM196 expression — LUAD

Explore this box plot interactively →