TMEM192

Across TCGA patient cohorts, TMEM192 mutation is significantly associated with the RNA expression of many other genes, with 453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM192-associated genes across cancer lineages are E2F6P1, MIR320B1, and TBC1D3P1-DHX40P1. Each is linked with TMEM192 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM192-to-partner and partner-to-TMEM192 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P1 grouped by TMEM192-low versus TMEM192-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM192→partner) and Y-score (partner→TMEM192) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E2F6P1 →	+0.030	+3.923	<.001	.009	3	4
BRCA	MIR320B1 →	+0.391	+7.731	<.001	.009	3	2
SKCM	TBC1D3P1-DHX40P1 →	+0.058	+6.080	<.001	.002	3	2
BRCA	RN7SL462P →	+0.153	+7.731	<.001	.009	3	1
UCEC	IGKV1OR2-118 →	+0.308	+2.981	<.001	<.001	3	1
UCEC	MIR6859-2 →	+0.409	+2.620	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 453 associations by consensus.

E2F6P1 by TMEM192 expression — UCEC

Explore this box plot interactively →