TMEM192

Across TCGA pan-cancer cohorts, TMEM192 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM192’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM192 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM192 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and KIRC are the cancer types where TMEM192 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM192 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.459	<.001	9	view →
LUSC	All	All	−0.573	<.001	6	view →
KIRC	Male	All	−0.383	<.001	5	view →
KIRP	Male	All	−0.568	<.001	4	view →
STAD	Male	II,III,IV	+0.552	.008	4	view →
BRCA	Female	All	−0.304	<.001	4	view →
COAD	Male	All	+0.443	<.001	3	view →
CHOL	All	All	−0.544	.019	2	view →
PRAD	All	All	+0.513	<.001	2	view →
UCEC	All	All	−0.447	.016	2	view →
HNSC	All	III,IV	+0.338	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM192–THCA

Open the THCA breakdown →