TMEM192

Across TCGA patient cohorts, TMEM192 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM192-associated genes across cancer lineages are Monocytes, CD8+ naive T-cells, and Class-switched memory B-cells. Each is linked with TMEM192 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM192-to-partner and partner-to-TMEM192 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by TMEM192-low versus TMEM192-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM192→partner) and Y-score (partner→TMEM192) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Monocytes →	+0.016	+5.810	<.001	.026	3	1
UCEC	CD8+ naive T-cells →	+0.043	+3.186	.001	.010	2	1
UCEC	Class-switched memory B-cells →	-0.057	-2.321	.045	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Monocytes by TMEM192 expression — SKCM

Explore this box plot interactively →