TMEM190

Across TCGA patient cohorts, TMEM190 mutation is significantly associated with the RNA expression of many other genes, with 437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM190-associated genes across cancer lineages are EEF1E1-BLOC1S5, MIR6515, and OR5L1. Each is linked with TMEM190 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM190-to-partner and partner-to-TMEM190 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by TMEM190-low versus TMEM190-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM190→partner) and Y-score (partner→TMEM190) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	EEF1E1-BLOC1S5 →	+0.040	+5.026	.006	.009	3	3
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	2
BRCA	OR5L1 →	+0.039	+7.731	<.001	.009	3	2
BRCA	TTTY25P →	+0.029	+8.055	<.001	.007	3	2
COAD	SLC20A1P3 →	+0.138	+5.917	<.001	.001	3	2
COAD	LINC02165 →	+0.173	+6.734	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 437 associations by consensus.

EEF1E1-BLOC1S5 by TMEM190 expression — STAD

Explore this box plot interactively →