TMEM190

Across TCGA pan-cancer cohorts, TMEM190 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM190 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM190 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM190 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PCPG show a favorable association.

KIRP, KIRC, and ACC are the cancer types where TMEM190 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.579	0.740	<.001	115	view →
KIRC	OS	Quartile	II,III,IV	0.398	0.599	.002	80	view →
ACC	OS	Tertile	II,III,IV	0.274	0.790	<.001	60	view →
HNSC	OS	Tertile	III,IV	0.786	0.653	.006	46	view →
SKCM	OS	Quartile	III,IV	0.378	0.819	<.001	37	view →
THCA	OS	Median	IV	0.574	0.939	.005	31	view →
LGG	DFS	Median	All	0.659	0.813	<.001	30	view →
COAD	OS	Median	II,III,IV	0.711	0.857	.012	23	view →
MESO	DFS	Median	IV	0.177	0.475	.004	18	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	17	view →
PCPG	DFS	Tertile	All	0.964	0.785	.004	16	view →
LIHC	DFS	Quartile	All	0.329	0.475	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM190–KIRP (OS)

Open the KIRP breakdown →