TMEM190

Across TCGA patient cohorts, TMEM190 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM190-associated genes across cancer lineages are Ku80, p62 Lck ligand, and Syk. Each is linked with TMEM190 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM190-to-partner and partner-to-TMEM190 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TMEM190-low versus TMEM190-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM190→partner) and Y-score (partner→TMEM190) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.308	+2.183	.012	.035	3	1
UCEC	p62 Lck ligand →	+0.401	+3.321	.018	.010	3	1
UCEC	Syk →	+0.418	+3.335	.033	.005	3	1
UCEC	VHL →	-1.373	-2.999	<.001	.035	3	1
UCEC	14-3-3_beta →	-0.145	-3.308	.005	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by TMEM190 expression — UCEC

Explore this box plot interactively →