TMEM190

Across TCGA cell cohorts, TMEM190 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM190-associated genes across cancer lineages are TAFA1, CENPVL3, and OOSP4A. Each is linked with TMEM190 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM190-to-partner and partner-to-TMEM190 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by TMEM190-low versus TMEM190-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM190→partner) and Y-score (partner→TMEM190) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	CENPVL3 →	+0.322	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OOSP4A →	+0.076	+3.793	.006	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TAFA1 by TMEM190 expression — LARGE_INTESTINE

Explore this box plot interactively →