TMEM19

Across TCGA patient cohorts, TMEM19 protein abundance is significantly associated with the RNA expression of many other genes, with 8,877 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM19-associated genes across cancer lineages are ROBO4, ILF3-DT, and TCEA1P2. Each is linked with TMEM19 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM19-to-partner and partner-to-TMEM19 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM19 versus ROBO4 in CCRCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM19→partner) and Y-score (partner→TMEM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ROBO4 →	-0.769	-0.733	<.001	<.001	3	4
OV	ILF3-DT →	-0.787	-0.484	.001	.001	3	3
BRCA	TCEA1P2 →	-0.451	-0.481	.004	<.001	3	3
BRCA	SEH1L →	-0.543	-0.737	<.001	<.001	3	3
COAD	DLST →	-0.592	-0.405	.004	<.001	3	3
COAD	PKN3 →	-0.753	-0.374	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,877 associations by consensus.

TMEM19 vs ROBO4 — CCRCC

Explore this scatter interactively →