TMEM19

Across TCGA pan-cancer cohorts, TMEM19 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM19’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM19 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM19 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where TMEM19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.224	<.001	11	view →
COAD	All	IV	−1.107	<.001	10	view →
LIHC	Male	All	+0.888	<.001	8	view →
KICH	All	All	−0.828	<.001	7	view →
LUAD	Female	III,IV	−0.682	<.001	6	view →
BRCA	All	All	+0.188	.005	4	view →
HNSC	Female	II,III,IV	+0.509	.013	3	view →
BLCA	All	All	+0.470	.025	3	view →
LUSC	All	All	+0.320	.003	3	view →
CHOL	All	All	+1.120	<.001	2	view →
STAD	Female	All	+0.687	.032	2	view →
PRAD	All	All	−0.448	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM19–THCA

Open the THCA breakdown →