TMEM19

Across TCGA patient cohorts, TMEM19 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM19-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with TMEM19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM19-to-partner and partner-to-TMEM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMEM19-low versus TMEM19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM19→partner) and Y-score (partner→TMEM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.217	+3.013	.022	.018	3	1
UCEC	Ku80 →	+0.246	+2.820	.021	.035	3	1
UCEC	MEK1 →	+0.433	+3.321	.008	.010	3	1
UCEC	MSH2 →	-0.293	-2.973	.004	.035	3	1
UCEC	p62 Lck ligand →	+0.485	+3.469	<.001	.002	3	1
UCEC	Annexin-1 →	+0.715	+3.341	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by TMEM19 expression — UCEC

Explore this box plot interactively →