TMEM19

Across TCGA cell cohorts, TMEM19 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM19-associated genes across cancer lineages are KRTAP19-5, S100G, and TEX26. Each is linked with TMEM19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM19-to-partner and partner-to-TMEM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-5 grouped by TMEM19-low versus TMEM19-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM19→partner) and Y-score (partner→TMEM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP19-5 →	+0.051	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	S100G →	+0.064	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX26 →	+0.025	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10J3 →	+0.032	+5.228	<.001	.005	3	1
LUNG_SCLC	ACTRT2 →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP19-5 by TMEM19 expression — BLOOD_Lymphoma

Explore this box plot interactively →