TMEM187

Across TCGA patient cohorts, TMEM187 mutation is significantly associated with the RNA expression of many other genes, with 831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM187-associated genes across cancer lineages are RN7SKP77, RNU6-342P, and MIR9-1. Each is linked with TMEM187 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM187-to-partner and partner-to-TMEM187 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP77 grouped by TMEM187-low versus TMEM187-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM187→partner) and Y-score (partner→TMEM187) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP77 →	+0.157	+5.037	.005	.009	3	2
BLCA	RNU6-342P →	+0.406	+4.840	<.001	.002	3	2
LUAD	MIR9-1 →	+0.276	+6.924	<.001	<.001	3	2
LUAD	LINC02222 →	+0.046	+5.087	<.001	.004	3	2
UCEC	KRTAP23-1 →	+0.174	+2.232	.005	.007	3	2
UCEC	KRTAP20-3 →	+0.061	+3.973	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 831 associations by consensus.

RN7SKP77 by TMEM187 expression — SKCM

Explore this box plot interactively →