TMEM187

Across TCGA pan-cancer cohorts, TMEM187 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM187 data layer compared with 4 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher TMEM187 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM187 expression acts as an unfavorable survival marker, although some lineages such as MESO and CHOL show a favorable association.

MESO, UVM, and CHOL are the cancer types where TMEM187 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.689	0.420	<.001	80	view →
UVM	OS	Tertile	All	0.435	0.796	.001	67	view →
CHOL	OS	Median	All	0.945	0.580	.006	61	view →
UCS	OS	Median	All	0.201	0.511	.004	44	view →
KIRC	DFS	Tertile	All	0.779	0.455	<.001	28	view →
LUAD	DFS	Median	IV	0.381	0.817	.002	24	view →
SCLC	OS	Quartile	All	0.785	0.502	.022	19	view →
STAD	DFS	Median	II,III,IV	0.697	0.579	.015	16	view →
COAD	DFS	Median	All	0.416	0.707	.002	15	view →
LIHC	DFS	Tertile	III,IV	0.438	0.183	.010	13	view →
LGG	OS	Tertile	All	0.343	0.505	.003	13	view →
SARC	DFS	Quartile	All	0.674	0.383	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM187–MESO (OS)

Open the MESO breakdown →