TMEM187

Across TCGA patient cohorts, TMEM187 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM187-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with TMEM187 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM187-to-partner and partner-to-TMEM187 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMEM187-low versus TMEM187-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM187→partner) and Y-score (partner→TMEM187) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.234	+3.906	.011	<.001	3	1
UCEC	MEK1 →	+0.356	+2.807	.025	.003	3	1
UCEC	MSH2 →	-0.328	-2.295	.001	.033	3	1
UCEC	PKC-a_pS657 →	-0.427	-2.575	.010	.010	3	1
UCEC	PKC-a →	-0.409	-2.807	.020	.003	3	1
UCEC	PR →	-0.229	-3.169	.037	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by TMEM187 expression — UCEC

Explore this box plot interactively →