Across TCGA patient cohorts, TMEM186 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM186-associated genes across cancer lineages are SUCLG2P4, OR7E25P, and IGHD3-16. Each is linked with TMEM186 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM186-to-partner and partner-to-TMEM186 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM186→partner) and Y-score (partner→TMEM186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SUCLG2P4 →	+0.220	+4.032	.003	.005	3	2
COAD	OR7E25P →	+0.102	+4.693	<.001	.007	3	2
UCEC	IGHD3-16 →	+1.711	+3.095	<.001	.002	3	2
UCEC	IGHD2-2 →	+1.969	+2.650	<.001	.007	3	2
SKCM	FABP5P5 →	+0.066	+4.884	<.001	.004	3	2
LUSC	RNU6-706P →	+0.421	+4.297	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Exploration

TMEM186 survival (RNA) · tumor vs normal (RNA) · all TMEM186 data types