Across TCGA cell cohorts, TMEM186 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,764 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM186-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, tRNA modification, and Mitochondrial respiratory chain complex assembly. Each is linked with TMEM186 in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM186-to-partner and partner-to-TMEM186 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM186→partner) and Y-score (partner→TMEM186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Symbiont-mediated disruption of host cell PML body →	+0.106	+0.836	<.001	<.001	3	15
BREAST	tRNA modification →	+0.037	+0.516	.002	<.001	3	9
PANCREAS	Mitochondrial respiratory chain complex assembly →	+0.056	+0.606	.003	.001	3	9
BONE	Telomerase RNA stabilization →	+0.100	+0.629	.004	<.001	2	10
BONE	Mitochondrial gene expression →	+0.147	+0.726	<.001	<.001	3	9
URINARY_TRACT	Mitochondrial fusion →	+0.057	+0.688	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

Exploration

TMEM186 survival (RNA) · tumor vs normal (RNA) · all TMEM186 data types