Across TCGA cell cohorts, TMEM186 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM186-associated genes across cancer lineages are IL21, CCR8, and DUSP29. Each is linked with TMEM186 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM186-to-partner and partner-to-TMEM186 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM186→partner) and Y-score (partner→TMEM186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL21 →	+0.143	+4.930	<.001	.008	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	DUSP29 →	+0.094	+4.930	<.001	.008	3	1
SOFT_TISSUE	GPX6 →	+0.023	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TMEM186 survival (RNA) · tumor vs normal (RNA) · all TMEM186 data types