TMEM185AP1

Across TCGA pan-cancer cohorts, TMEM185AP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TMEM185AP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TMEM185AP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM185AP1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUSC, LUAD, and ESCA are the cancer types where TMEM185AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM185AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.125	.001	4	view →
LUAD	Male	II,III,IV	−0.112	.008	3	view →
ESCA	Male	All	+0.280	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TMEM185AP1–LUSC

Open the LUSC breakdown →