transmembrane protein 185A pseudogene 1Genealiases: FAM11C · TMEM185AL
Q-omics provides the consensus-scored TMEM185AP1 profile across patient tissues and cancer cell-line models. TMEM185AP1 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, TMEM185AP1 is differentially expressed in 3, with the highest sampling consensus in LUSC. Additionally, TMEM185AP1 RNA expression shows 4,768 significant protein co-abundance associations, with the highest sampling consensus in OV. Together, these results highlight READ, LUSC, and OV as cancer lineages where TMEM185AP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM185AP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM185AP1 survival associations across molecular data types. TMEM185AP1 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM185AP1 RNA expression–survival associations across cancer types. High TMEM185AP1 expression shows unfavorable associations in READ, COAD, STAD and BRCA, but favorable associations in ESCA and HNSC. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .007). Together, the overview and detailed table identify READ as the clearest survival context for TMEM185AP1 RNA expression.
This table summarizes TMEM185AP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for TMEM185AP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM185AP1 shows lower tumor expression in LUAD and higher tumor expression in LUSC and ESCA. The LUSC box plot shows higher TMEM185AP1 RNA expression in tumor versus normal tissue (log2 FC = +0.125, t-test p = .001).
This table shows molecular features associated with TMEM185AP1 in patient tissues and cancer cell lines. In patient samples, TMEM185AP1 shows the broadest associations at the RNA and protein expression levels, with OV recurring as the lineage with the largest associated feature set.
