TMEM185A

Across TCGA patient cohorts, TMEM185A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TMEM185A-associated genes across cancer lineages are 4E-BP1, 4E-BP1_pT37_T46, and eIF4E. Each is linked with TMEM185A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM185A-to-partner and partner-to-TMEM185A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TMEM185A-low versus TMEM185A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM185A→partner) and Y-score (partner→TMEM185A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.302	+3.199	.016	.009	3	2
COAD	4E-BP1_pT37_T46 →	+0.456	+2.815	.013	.036	3	2
UCEC	eIF4E →	+0.204	+2.584	.038	.011	3	1
UCEC	Notch1 →	+0.189	+3.179	.003	.010	2	2
UCEC	Rad50 →	-0.326	-2.584	.003	.011	3	1
UCEC	C-Raf →	+0.140	+3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

4E-BP1 by TMEM185A expression — UCEC

Explore this box plot interactively →