TMEM185A

Across TCGA pan-cancer cohorts, TMEM185A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM185A data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM185A RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM185A expression acts as an unfavorable survival marker, although some lineages such as UVM and SCLC show a favorable association.

UVM, SCLC, and KIRC are the cancer types where TMEM185A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.816	0.417	<.001	110	view →
SCLC	OS	Quartile	III,IV	0.848	0.318	<.001	77	view →
KIRC	DFS	Median	All	0.752	0.503	<.001	48	view →
PAAD	OS	Median	All	0.619	0.248	<.001	33	view →
HNSC	OS	Median	III,IV	0.548	0.790	.001	22	view →
THYM	DFS	Tertile	III,IV	1.000	0.216	.011	17	view →
KICH	OS	Tertile	All	0.758	1.000	.012	17	view →
LIHC	OS	Quartile	All	0.680	0.848	.001	17	view →
LGG	OS	Tertile	All	0.748	0.955	<.001	15	view →
ACC	DFS	Quartile	All	0.240	0.665	.004	15	view →
COAD	DFS	Median	All	0.419	0.636	.016	14	view →
CESC	OS	Quartile	II,III,IV	0.935	0.685	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM185A–UVM (OS)

Open the UVM breakdown →