TMEM184A

Across TCGA patient cohorts, TMEM184A mutation is significantly associated with the RNA expression of many other genes, with 2,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM184A-associated genes across cancer lineages are MTMR12, SLC7A11, and C18orf25. Each is linked with TMEM184A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM184A-to-partner and partner-to-TMEM184A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTMR12 grouped by TMEM184A-low versus TMEM184A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM184A→partner) and Y-score (partner→TMEM184A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTMR12 →	+0.510	+2.708	.003	.003	3	2
UCEC	SLC7A11 →	+0.800	+2.938	.001	<.001	3	2
UCEC	C18orf25 →	+0.393	+1.747	.004	.004	3	2
UCEC	SMARCA5 →	+0.498	+1.947	.003	.008	3	2
UCEC	EME1 →	+0.510	+1.747	.002	.004	3	2
UCEC	VPS37A →	+0.599	+2.081	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,246 associations by consensus.

MTMR12 by TMEM184A expression — UCEC

Explore this box plot interactively →