TMEM184A

Across TCGA cell cohorts, TMEM184A mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM184A-associated genes across cancer lineages are GFRA4, ADAMTS19, and RORB. Each is linked with TMEM184A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM184A-to-partner and partner-to-TMEM184A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by TMEM184A-low versus TMEM184A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM184A→partner) and Y-score (partner→TMEM184A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.021	+3.760	<.001	<.001	3	2
LARGE_INTESTINE	ADAMTS19 →	+0.685	+3.541	.004	.004	3	1
LARGE_INTESTINE	RORB →	+0.111	+4.035	<.001	.003	3	1
LARGE_INTESTINE	KCNU1 →	+0.051	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	TBL1Y →	+0.112	+3.217	.001	.006	3	1
SKIN	C5orf52 →	+0.041	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

GFRA4 by TMEM184A expression — LARGE_INTESTINE

Explore this box plot interactively →