TMEM181

Across TCGA patient cohorts, TMEM181 mutation is significantly associated with the RNA expression of many other genes, with 997 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM181-associated genes across cancer lineages are RN7SL472P, MIR3135A, and RN7SL447P. Each is linked with TMEM181 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM181-to-partner and partner-to-TMEM181 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL472P grouped by TMEM181-low versus TMEM181-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM181→partner) and Y-score (partner→TMEM181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL472P →	+0.544	+2.855	.003	.009	3	2
COAD	MIR3135A →	+0.492	+3.865	<.001	.002	3	2
CESC	RN7SL447P →	+0.183	+5.201	<.001	.007	3	2
CESC	CICP28 →	+0.025	+5.010	<.001	.009	3	2
UCEC	SF3A2 →	+0.549	+3.364	<.001	.004	3	2
UCEC	ULK3 →	+0.540	+3.617	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 997 associations by consensus.

RN7SL472P by TMEM181 expression — COAD

Explore this box plot interactively →