TMEM179

Across TCGA pan-cancer cohorts, TMEM179 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM179 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM179 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM179 expression acts as an unfavorable survival marker.

HNSC, UCEC, and BRCA are the cancer types where TMEM179 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.158	0.712	<.001	45	view →
UCEC	OS	Median	III,IV	0.061	0.588	.018	12	view →
BRCA	DFS	Median	All	0.745	0.949	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM179–HNSC (DFS)

Open the HNSC breakdown →