TMEM178B

Across TCGA cell cohorts, TMEM178B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM178B-associated genes across cancer lineages are LACRT, CCER1, and MBD3L2. Each is linked with TMEM178B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM178B-to-partner and partner-to-TMEM178B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACRT grouped by TMEM178B-low versus TMEM178B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM178B→partner) and Y-score (partner→TMEM178B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LACRT →	+0.230	+4.981	<.001	.008	3	1
CNS	CCER1 →	+0.016	+5.754	<.001	.002	3	1
CNS	MBD3L2 →	+2.479	+4.981	<.001	.008	3	1
LARGE_INTESTINE	GRM6 →	+0.072	+4.115	.001	.001	3	1
LARGE_INTESTINE	VWC2L →	+0.007	+3.345	.006	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.024	+3.766	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LACRT by TMEM178B expression — CNS

Explore this box plot interactively →