TMEM178A

Across TCGA patient cohorts, TMEM178A mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM178A-associated genes across cancer lineages are eIF4E, Annexin-1, and Src_pY527. Each is linked with TMEM178A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM178A-to-partner and partner-to-TMEM178A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMEM178A-low versus TMEM178A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM178A→partner) and Y-score (partner→TMEM178A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.181	+1.700	.043	.044	3	2
UCEC	Annexin-1 →	+0.659	+2.341	.003	.019	3	2
UCEC	Src_pY527 →	-0.462	-3.311	.011	.010	3	2
UCEC	eEF2 →	+0.427	+2.999	.004	.035	3	1
UCEC	EGFR →	-0.210	-2.222	.001	.011	3	1
UCEC	A-Raf_pS299 →	-0.100	-3.169	.048	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by TMEM178A expression — UCEC

Explore this box plot interactively →