TMEM178A

Across TCGA pan-cancer cohorts, TMEM178A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM178A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM178A RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM178A is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where TMEM178A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM178A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−3.620	<.001	12	view →
KIRP	Female	II,III,IV	−3.808	<.001	11	view →
KICH	Male	All	−3.691	<.001	11	view →
LUAD	Female	III,IV	−2.027	<.001	9	view →
THCA	Male	III,IV	−1.795	<.001	9	view →
LUSC	Female	II,III,IV	−2.620	<.001	8	view →
BRCA	Female	All	−1.771	<.001	6	view →
UCEC	All	All	+1.197	.007	6	view →
HNSC	All	All	−0.701	<.001	5	view →
CHOL	All	All	+2.385	.002	2	view →
PRAD	All	All	+1.867	<.001	2	view →
BLCA	Male	IV	−1.377	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM178A–KIRC

Open the KIRC breakdown →