TMEM177

Across TCGA patient cohorts, TMEM177 protein abundance is significantly associated with the RNA expression of many other genes, with 6,485 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM177-associated genes across cancer lineages are RPS20P15, HMGN2P38, and MIR181A1HG. Each is linked with TMEM177 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM177-to-partner and partner-to-TMEM177 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM177 versus RPS20P15 in UCEC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM177→partner) and Y-score (partner→TMEM177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS20P15 →	-0.901	-0.560	<.001	<.001	3	3
UCEC	HMGN2P38 →	-0.741	-0.519	.002	.002	3	3
LSCC	MIR181A1HG →	-0.610	-0.368	.001	.003	3	3
BRCA	MSANTD2 →	-0.524	-0.383	.002	<.001	3	3
LSCC	KCTD12 →	-0.736	-0.424	<.001	<.001	3	3
GBM	GLT1D1 →	+0.836	+0.425	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,485 associations by consensus.

TMEM177 vs RPS20P15 — UCEC

Explore this scatter interactively →