TMEM175

Across TCGA patient cohorts, TMEM175 protein abundance is significantly associated with the RNA expression of many other genes, with 7,361 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM175-associated genes across cancer lineages are KNOP1, BRIX1, and ANLN. Each is linked with TMEM175 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM175-to-partner and partner-to-TMEM175 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM175 versus KNOP1 in UCEC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM175→partner) and Y-score (partner→TMEM175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KNOP1 →	-0.722	-1.144	.003	<.001	3	3
LUAD	BRIX1 →	-0.471	-0.387	.003	.006	3	3
UCEC	ANLN →	-1.270	-0.893	<.001	.002	3	3
UCEC	MCM7 →	-1.238	-0.775	.004	.009	3	3
LSCC	RCOR2 →	-1.044	-0.500	.001	<.001	3	3
UCEC	CKAP5 →	-0.878	-0.893	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,361 associations by consensus.

TMEM175 vs KNOP1 — UCEC

Explore this scatter interactively →