TMEM174

Across TCGA patient cohorts, TMEM174 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,031 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TMEM174-associated GO terms across cancer lineages are Regulation of stress-activated protein kinase signaling cascade, Monocarboxylic acid catabolic process, and Dicarboxylic acid metabolic process. Each is linked with TMEM174 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM174-to-partner and partner-to-TMEM174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stress-activated protein kinase signaling cascade grouped by TMEM174-low versus TMEM174-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM174→partner) and Y-score (partner→TMEM174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of stress-activated protein kinase signaling cascade →	+0.059	+0.031	<.001	<.001	3	8
ESCA	Monocarboxylic acid catabolic process →	+0.057	+0.027	<.001	.005	3	8
ESCA	Dicarboxylic acid metabolic process →	+0.057	+0.024	<.001	<.001	3	8
STAD	Positive regulation of glycolytic process →	+0.057	+0.030	<.001	<.001	3	8
STAD	Glycerophospholipid biosynthetic process →	+0.066	+0.033	<.001	<.001	3	8
STAD	Phospholipid biosynthetic process →	+0.068	+0.028	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,031 associations by consensus.

Regulation of stress-activated protein kinase signaling cascade by TMEM174 expression — STAD

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