TMEM174

Across TCGA patient cohorts, TMEM174 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM174-associated genes across cancer lineages are KLF3P2, SNORD116-16, and MIR6803. Each is linked with TMEM174 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM174-to-partner and partner-to-TMEM174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF3P2 grouped by TMEM174-low versus TMEM174-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM174→partner) and Y-score (partner→TMEM174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KLF3P2 →	+0.177	+4.795	<.001	.001	3	2
SKCM	SNORD116-16 →	+0.424	+2.693	.001	.001	3	2
STAD	MIR6803 →	+0.451	+4.798	<.001	.006	3	2
SKCM	RN7SL712P →	+0.062	+3.897	<.001	.009	3	2
SKCM	H3P36 →	-0.442	-3.453	.008	.005	3	1
SKCM	RN7SL794P →	+0.117	+2.731	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

KLF3P2 by TMEM174 expression — LUSC

Explore this box plot interactively →