TMEM171

Across TCGA patient cohorts, TMEM171 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM171-associated genes across cancer lineages are ER-alpha, JNK2, and Ku80. Each is linked with TMEM171 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM171-to-partner and partner-to-TMEM171 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by TMEM171-low versus TMEM171-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM171→partner) and Y-score (partner→TMEM171) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-0.843	-3.000	.015	.036	3	1
UCEC	JNK2 →	+0.193	+2.222	.022	.011	3	1
UCEC	Ku80 →	+0.199	+1.713	.047	.027	3	1
UCEC	MEK1 →	+0.436	+2.906	.004	.001	3	1
UCEC	PAI-1 →	+0.305	+2.222	.036	.011	3	1
UCEC	Tuberin →	+0.350	+3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ER-alpha by TMEM171 expression — UCEC

Explore this box plot interactively →