TMEM169

Across TCGA patient cohorts, TMEM169 protein abundance is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM169-associated genes across cancer lineages are ANKRD54, RTCB, and KCTD17. Each is linked with TMEM169 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM169 versus ANKRD54 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANKRD54 →	+0.548	+0.583	<.001	<.001	3	1
GBM	RTCB →	+0.373	+0.483	<.001	.005	3	1
GBM	KCTD17 →	+0.588	+0.536	<.001	<.001	3	1
GBM	PYGL →	-0.774	-0.625	<.001	<.001	3	1
GBM	HIF1A →	-0.697	-0.596	<.001	<.001	3	1
GBM	SLC8A3 →	+1.395	+0.666	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

TMEM169 vs ANKRD54 — GBM

Explore this scatter interactively →