TMEM169

Across TCGA patient cohorts, TMEM169 mutation is significantly associated with the RNA expression of many other genes, with 1,627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM169-associated genes across cancer lineages are YWHAE, RRM2, and NUP188. Each is linked with TMEM169 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YWHAE grouped by TMEM169-low versus TMEM169-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YWHAE →	+0.345	+2.617	.005	<.001	3	3
UCEC	RRM2 →	+0.988	+3.914	<.001	<.001	3	3
UCEC	NUP188 →	+0.605	+2.847	<.001	.001	3	3
SKCM	MIR4444-2 →	+0.439	+4.207	<.001	<.001	3	3
UCEC	SCO1 →	+0.487	+3.823	<.001	<.001	3	3
UCEC	GEMIN4 →	+0.459	+3.516	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,627 associations by consensus.

YWHAE by TMEM169 expression — UCEC

Explore this box plot interactively →