TMEM169

Across TCGA patient cohorts, TMEM169 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM169-associated genes across cancer lineages are eEF2, JNK2, and MEK1. Each is linked with TMEM169 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TMEM169-low versus TMEM169-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.292	+1.807	.048	.027	3	2
UCEC	JNK2 →	+0.225	+2.331	.006	.019	3	2
UCEC	MEK1 →	+0.397	+2.584	.008	.010	3	2
UCEC	ATM →	-0.389	-3.308	.038	.009	3	2
UCEC	4E-BP1_pT37_T46 →	-0.442	-3.446	.004	.005	3	2
COAD	PTEN →	+0.160	+2.815	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by TMEM169 expression — UCEC

Explore this box plot interactively →