TMEM169

Across TCGA cell cohorts, TMEM169 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,887 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM169-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Mitotic cytokinesis, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with TMEM169 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by TMEM169-low versus TMEM169-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.124	+0.458	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Mitotic cytokinesis →	+0.076	+0.256	.001	.001	3	9
BLOOD_Lymphoma	Regulation of syncytium formation by plasma membrane fusion →	+0.083	+0.418	<.001	<.001	3	9
STOMACH	Negative regulation of gene expression, epigenetic →	+0.062	+0.924	<.001	.001	3	9
BREAST	Cytokinesis →	+0.104	+0.465	<.001	<.001	3	8
LUNG_SCLC	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.182	+1.663	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,887 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by TMEM169 expression — BREAST

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