TMEM169

Across TCGA cell cohorts, TMEM169 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible TMEM169-associated genes across cancer lineages are VWA3B, OR13F1, and PRR27. Each is linked with TMEM169 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWA3B grouped by TMEM169-low versus TMEM169-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VWA3B →	+0.034	+4.285	<.001	.003	3	1
BLOOD_Myeloma	OR13F1 →	+0.060	+3.906	<.001	.009	3	1
BLOOD_Myeloma	PRR27 →	+0.019	+3.906	<.001	.009	3	1
BLOOD_Myeloma	DUSP29 →	+0.190	+4.285	<.001	.003	3	1
BLOOD_Myeloma	PRR23A →	+0.066	+4.285	<.001	.003	3	1
BLOOD_Myeloma	CSNKA2IP →	+0.012	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VWA3B by TMEM169 expression — BLOOD_Myeloma

Explore this box plot interactively →