TMEM168

Across TCGA patient cohorts, TMEM168 protein abundance is significantly associated with the RNA expression of many other genes, with 5,322 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM168-associated genes across cancer lineages are ZBED2, MKLN1-AS, and GBP5. Each is linked with TMEM168 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM168-to-partner and partner-to-TMEM168 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM168 versus ZBED2 in UCEC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM168→partner) and Y-score (partner→TMEM168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBED2 →	-0.925	-0.329	.004	.003	3	5
COAD	MKLN1-AS →	+0.434	+0.350	<.001	.001	3	4
BRCA	GBP5 →	-1.133	-0.462	.003	.005	3	4
BRCA	COTL1 →	-0.991	-0.663	<.001	<.001	3	3
OV	MFAP2 →	-1.300	-0.337	.006	.001	3	3
OV	ARID5A →	-0.548	-0.271	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,322 associations by consensus.

TMEM168 vs ZBED2 — UCEC

Explore this scatter interactively →